Most businesses need licenses and permits to operate. The type of license or permit you need depends on your industry and the state in which you are located. License and permit requirements also affect where you locate your business, how much you'll have to spend for remodeling, and whether or not you'll have to provide off-street parking.

Zoning Requirements

It is important to check the zoning requirements for the area where you are acquiring your business. The zoning requirements may affect the type of business that you are intending to operate in a particular area. 

Environmental Concerns

If you are acquiring real property along with the acquisition of the business, it is important to check the environmental regulations in the area.

More Information
Environmental Protection Agency